| Identification | Back Directory | [Name]
2,3-Dichloro-5-(trichloromethyl)pyridine | [CAS]
69045-83-6 | [Synonyms]
2 3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDIN&
2,3-Dichloro-5-(trichloromethyl)pyridine
Pyridine,2,3-dichloro-5-(trichloromethyl)-
2,3-Dichloro-5-(trichloromethyl)pyridine ISO 9001：2015 REACH | [EINECS(EC#)]
614-912-7 | [Molecular Formula]
C6H2Cl5N | [MDL Number]
MFCD00042243 | [MOL File]
69045-83-6.mol | [Molecular Weight]
265.35 |
| Hazard Information | Back Directory | [Uses]
2,3-dichloro-5-(trifluoromethyl)pyridine (DCTF) is an important organic intermediate for the agrochemical industry in particular for use in the synthesis of fluazinam and fluopicolide as well as other pesticidal active pyridine compounds. | [Synthesis]
Conversion of Nicotinic acid to 2,3-dichloro-5-(trichloromethyl)pyridine. Nicotinic acid (2 g, 16.25 mmole) and phosphorous pentachloride (27 g, 130 mmole) was mixed in a 50 ml Teflon autoclave. The autoclave was closed and heated in a 180 °C warm metal block. After 48 hours was the autoclave cooled to 25 °C and opened. The resulting suspension was quenched in a mixture of NaOH (10 %) and dichlorom ethane under stirring, keeping the temperature below 30 °C. The phases were separated and the organic phase was evaporated to dryness to get the crude product. The product was hereafter distilled and 2,8 g of 2,3-dichloro-5-(trichloromethyl)pyridine was obtained (65% yield). |
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