| Identification | Back Directory | [Name]
2,3-Dichloro-5-(trichloromethyl)pyridine | [CAS]
69045-83-6 | [Synonyms]
2 3-DICHLORO-5-(TRICHLOROMETHYL)PYRIDIN&
2,3-Dichloro-5-(trichloromethyl)pyridine
Pyridine,2,3-dichloro-5-(trichloromethyl)-
2,3-Dichloro-5-(trichloromethyl)pyridine ISO 9001：2015 REACH | [EINECS(EC#)]
614-912-7 | [Molecular Formula]
C6H2Cl5N | [MDL Number]
MFCD00042243 | [MOL File]
69045-83-6.mol | [Molecular Weight]
265.35 |
| Chemical Properties | Back Directory | [Boiling point ]
278-279 °C(lit.)
| [density ]
1.636 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5900(lit.)
| [Fp ]
150 °F
| [storage temp. ]
Inert atmosphere,2-8°C | [pka]
-3.03±0.10(Predicted) | [InChI]
InChI=1S/C6H2Cl5N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H | [InChIKey]
XVBWGQSXLITICX-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C(C(Cl)(Cl)Cl)C=C1Cl | [EPA Substance Registry System]
2,3-Dichloro-5-(trichloromethyl)pyridine (69045-83-6) |
| Hazard Information | Back Directory | [Uses]
2,3-dichloro-5-(trifluoromethyl)pyridine (DCTF) is an important organic intermediate for the agrochemical industry in particular for use in the synthesis of fluazinam and fluopicolide as well as other pesticidal active pyridine compounds. | [Synthesis]
Conversion of Nicotinic acid to 2,3-dichloro-5-(trichloromethyl)pyridine. Nicotinic acid (2 g, 16.25 mmole) and phosphorous pentachloride (27 g, 130 mmole) was mixed in a 50 ml Teflon autoclave. The autoclave was closed and heated in a 180 °C warm metal block. After 48 hours was the autoclave cooled to 25 °C and opened. The resulting suspension was quenched in a mixture of NaOH (10 %) and dichlorom ethane under stirring, keeping the temperature below 30 °C. The phases were separated and the organic phase was evaporated to dryness to get the crude product. The product was hereafter distilled and 2,8 g of 2,3-dichloro-5-(trichloromethyl)pyridine was obtained (65% yield). | [References]
[1] Patent: CN106748985, 2017, A. Location in patent: Paragraph 0030; 0032; 0033; 0035
[2] Patent: CN107935920, 2018, A. Location in patent: Paragraph 0026; 0031; 0034 |
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