| Identification | Back Directory | [Name]
5-Ethynyl uridine | [CAS]
69075-42-9 | [Synonyms]
5-EU
5-Ethynyl uridine
Uridine, 5-ethynyl-
5-Ethynyl Uridine (EU)
5-Ethynyluridine (5-EU)
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpy
5-ETHYNYL URIDINE; 1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-ETHYNYLPY
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione | [EINECS(EC#)]
500-100-4 | [Molecular Formula]
C11H12N2O6 | [MDL Number]
MFCD00876719 | [MOL File]
69075-42-9.mol | [Molecular Weight]
268.22 |
| Chemical Properties | Back Directory | [Melting point ]
>164oC (dec.) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
8.29±0.10(Predicted) | [color ]
Off-White to Pale Beige | [Appearance]
off white solid | [InChI]
InChI=1S/C11H12N2O6/c1-2-5-3-13(11(18)12-9(5)17)10-8(16)7(15)6(4-14)19-10/h1,3,6-8,10,14-16H,4H2,(H,12,17,18)/t6-,7-,8-,10-/m1/s1 | [InChIKey]
QCWBIPKYTBFWHH-FDDDBJFASA-N | [SMILES]
OC[C@H]1O[C@@H](N2C=C(C#C)C(=O)NC2=O)[C@H](O)[C@@H]1O |
| Hazard Information | Back Directory | [Description]
5-Ethynyl uridine (5-EU) is an alkyne-containing metabolic labeling reagent used to detect global RNA transcription temporally and spatially in both in-vitro and in-vivo with the modified nucleotide. The alkyne handler can be used for subsequent ligation to azide-containing molecules through a highly efficient click chemistry reaction. | [Uses]
5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA. | [reaction suitability]
reaction type: click chemistry | [storage]
Store at -20°C |
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