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691388-62-2

691388-62-2 Structure

691388-62-2 Structure
IdentificationBack Directory
[Name]

2-Cyano-5-[5-(2,5-dichloro-phenyl)-furan-2-yl]-penta-2,4-dienethioic acid amide
[CAS]

691388-62-2
[Synonyms]

PIKC98
PIK-C98
PIK C98
2-Cyano-5-[5-(2,5-dichloro-phenyl)-furan-2-yl]-penta-2,4-dienethioic acid amide
[Molecular Formula]

C16H10Cl2N2OS
[MDL Number]

MFCD05827248
[MOL File]

691388-62-2.mol
[Molecular Weight]

349.23
Chemical PropertiesBack Directory
[Boiling point ]

527.8±60.0 °C(Predicted)
[density ]

1.411±0.06 g/cm3(Predicted)
[pka]

10.76±0.29(Predicted)
Hazard InformationBack Directory
[Description]

PIK-C98 is a PI3K inhibitor. It acts by displaying potent preclinical activity against multiple myeloma.
[Uses]

PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
[IC 50]

PI3Kα: 0.59 μM (IC50); PI3Kβ: 1.64 μM (IC50); PI3Kδ: 3.65 μM (IC50); PI3Kγ: 0.74 μM (IC50)
[References]

[1] Zhu J, et, al. A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma. Oncotarget. 2015 Jan 1;6(1):185-95. DOI:10.18632/oncotarget.2688
691388-62-2 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Princeton BioMolecular Research, Inc.  
Tel: 732 355 9920 ext. 102
Website: www.princetonbio.com
Company Name: OTAVA chemicals  
Tel: 416 305 9979 (Canada)
Website: www.otavachemicals.com
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