| Identification | Back Directory | [Name]
2-Cyano-5-[5-(2,5-dichloro-phenyl)-furan-2-yl]-penta-2,4-dienethioic acid amide | [CAS]
691388-62-2 | [Synonyms]
PIKC98 PIK-C98 PIK C98 2-Cyano-5-[5-(2,5-dichloro-phenyl)-furan-2-yl]-penta-2,4-dienethioic acid amide | [Molecular Formula]
C16H10Cl2N2OS | [MDL Number]
MFCD05827248 | [MOL File]
691388-62-2.mol | [Molecular Weight]
349.23 |
| Hazard Information | Back Directory | [Description]
PIK-C98 is a PI3K inhibitor. It acts by displaying potent preclinical activity against multiple myeloma. | [Uses]
PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1]. | [IC 50]
PI3Kα: 0.59 μM (IC50); PI3Kβ: 1.64 μM (IC50); PI3Kδ: 3.65 μM (IC50); PI3Kγ: 0.74 μM (IC50) | [References]
[1] Zhu J, et, al. A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma. Oncotarget. 2015 Jan 1;6(1):185-95. DOI:10.18632/oncotarget.2688 |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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