| Identification | Back Directory | [Name]
Ethanone, 1-(4-cyclopropylphenyl)- (9CI) | [CAS]
6921-45-5 | [Synonyms]
Ethanone,1-(4-cyclopropylphenyl)-
Ethanone, 1-(4-cyclopropylphenyl)- (9CI) | [Molecular Formula]
C11H12O | [MDL Number]
MFCD00102381 | [MOL File]
6921-45-5.mol | [Molecular Weight]
160.21 |
| Chemical Properties | Back Directory | [Melting point ]
35-36 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
114-119 °C(Press: 2.5-2.9 Torr) | [density ]
1.075±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
Yellow to brown <35°C Solid,>36°C Liquid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: Potassium phosphate (0.75 mmol) and Catalyst IIe (1 mol%) were added to a mixture of toluene (2.0 mL) and water (100 μL) containing p-bromoacetophenone (0.25 mmol) and cyclo-propylboronic acid (0.5 mmol) under nitrogen protection. The reaction mixture was heated to 100 °C, kept for an appropriate time and then cooled to room temperature. After the reaction was completed, it was diluted by adding water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, concentrated by evaporation and purified by silica gel column chromatography to afford the target product 1-(4-cyclopropylphenyl)ethanone. | [References]
[1] Tetrahedron, 2012, vol. 68, # 3, p. 900 - 905
[2] Synthetic Communications, 2006, vol. 36, # 1, p. 121 - 128
[3] Patent: WO2015/59618, 2015, A1. Location in patent: Page/Page column 42
[4] Journal of the American Chemical Society, 2016, vol. 138, # 20, p. 6598 - 6609
[5] Patent: WO2016/201168, 2016, A1. Location in patent: Paragraph 0662 |
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| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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