| Hazard Information | Back Directory | [Description]
Curcuphenol in concentrations in the range of 29-116 μg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. Findings suggest that curcuphenol has antiproliferative and pro-apoptotic properties. | [Uses]
Curcuphenol is a compound with histone deacetylase enhancing activity and has the activity of reversing immune escape. Curcuphenol can reverse the immune escape of tumors by restoring the expression of antigen presentation machinery. Its two synthetic analogs have histone deacetylase enhancing activity and play an important role in the immune recognition of metastatic tumors. | [References]
[1] Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours DOI:10.3389/fphar.2023.1119620 |
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