| Identification | Back Directory | [Name]
Piperidin-4-yl-pyrimidin-2-yl-amine | [CAS]
69385-85-9 | [Synonyms]
N-(4-piperidinyl)-2-pyrimidinamine
2-Pyrimidinamine, N-4-piperidinyl-
PIPERIDIN-4-YL-PYRIMIDIN-2-YL-AMINE
Piperidin-4-yl-pyrimidin-2-yl-amine ISO 9001：2015 REACH | [Molecular Formula]
C9H14N4 | [MDL Number]
MFCD09936150 | [MOL File]
69385-85-9.mol | [Molecular Weight]
178.23 |
| Chemical Properties | Back Directory | [Boiling point ]
345.3±52.0 °C(Predicted) | [density ]
1.158±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
9.97±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of N-(piperidin-4-yl)pyrimidin-2-amine from the compound (CAS:76167-42-5) was as follows: first, 22-N-piperidin-4-ylpyrimidin-2-amine was prepared. 10% palladium hydroxide (200 mg) was added to the solution formed by dissolving the product of preparation 20 (3 g, 11 mmol) in ethanol (300 mL). Subsequently, the reaction mixture was subjected to a stirring reaction at 60°C under a 60 psi hydrogen atmosphere for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through Arbocel and the filter cake was washed with ethanol. Finally, the filtrate was concentrated under reduced pressure to obtain the target product N-(piperidin-4-yl)pyrimidin-2-amine in quantitative yield of 2 g. | [References]
[1] Patent: WO2005/105779, 2005, A1. Location in patent: Page/Page column 44 |
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Cool Pharm, Ltd
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021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
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Grader reagent
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18221735425 |
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www.shxinping.net |
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