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69502-27-8

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69502-27-8 Structure

69502-27-8 Structure
IdentificationBack Directory
[Name]

Heptaethylene glycol di(p-toluenesulfonate)
[CAS]

69502-27-8
[Synonyms]

Tos-PEG8-Tos
Bis-Tos-PEG7
Heptaethylene glycol di(p-toluenesulfonate)
3,6,9,12,15,18-Hexaoxaicosane-1,20-diyl bis(4-methylbenzenesulfonate)
3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol, 1,20-bis(4-methylbenzenesulfonate)
[Molecular Formula]

C28H42O12S2
[MDL Number]

MFCD06292255
[MOL File]

69502-27-8.mol
[Molecular Weight]

634.756
Chemical PropertiesBack Directory
[form ]

Liquid
[color ]

Colorless to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard InformationBack Directory
[Description]

Tos-PEG8-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
[Uses]

Bis-Tos-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

Heptaethylene glycol di(p-toluenesulfonate)(69502-27-8)1HNMR
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