| Identification | Back Directory | [Name]
(5-chloro-1H-benzo[d]imidazol-2-yl)methanol | [CAS]
6953-65-7 | [Synonyms]
2-Benzimidazolemethanol, 5-chloro-
(6-Chloro-1H-benzo[d]imidazol-2-yl)
6-Chloro-1H-Benzimidazole-2-methanol
5-Chloro-2-hydroxymethylbenzimidazole
Benzimidazole, 5-chloro-2-hydroxymethyl-
1H-Benzimidazole-2-methanol,5-chloro-(9CI)
(5-chloro-1H-benzo[d]imidazol-2-yl)methanol
(6-Chloro-1H-benzo[d]iMidazol-2-yl)Methanol
(5-chloro-1H-benzimidazol-2-yl)methanol(SALTDATA: 0.06NH4Cl) | [Molecular Formula]
C8H7ClN2O | [MDL Number]
MFCD09971879 | [MOL File]
6953-65-7.mol | [Molecular Weight]
182.61 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C | [Boiling point ]
443.9±25.0 °C(Predicted) | [density ]
1.510±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
10.17±0.10(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
a) A mixture of 4-chloro-1,2-benzenediamine (105 g, 736 mmol, 1 eq.) and ethanoic acid (112 g, 2 eq.) in xylene (1500 mL) was stirred and refluxed at 150 °C for 4 h. The reaction was carried out with the addition of 3N hydrochloric acid (480 mL). Upon completion of the reaction, the reaction solution was cooled to 60 °C and acidified by slow addition of 3N hydrochloric acid (480 mL), followed by adjusting the pH with ammonia to 7-8. The reaction mixture was filtered and the solid product was collected and washed with water and tert-butyl methyl ether sequentially to afford 123 g of (6-chloro-1H-benzimidazol-2-yl)methanol in 82% yield. | [References]
[1] Molecules, 2015, vol. 20, # 8, p. 15206 - 15223
[2] Patent: WO2014/60411, 2014, A1. Location in patent: Page/Page column 58
[3] Patent: WO2015/158653, 2015, A1. Location in patent: Page/Page column 37; 38
[4] Annales Pharmaceutiques Francaises, 2003, vol. 61, # 1, p. 57 - 61
[5] Bulletin of the Korean Chemical Society, 2013, vol. 34, # 4, p. 1272 - 1274 |
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