| Identification | Back Directory | [Name]
Carbaprostacyclin methyl ester | [CAS]
69552-55-2 | [Synonyms]
Carbaprostacyclin methyl ester
Carbaprostacyclin methyl ester Exclusive | [Molecular Formula]
C22H36O4 | [MDL Number]
MFCD18428037 | [MOL File]
69552-55-2.mol | [Molecular Weight]
364.52 |
| Chemical Properties | Back Directory | [Boiling point ]
479.2±45.0 °C(Predicted) | [density ]
1.128±0.06 g/cm3(Predicted) | [solubility ]
DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): .1 mg/ml | [pka]
14.56±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Carbaprostacyclin is a stable analog of prostacyclin (prostaglandin I2) which can activate the prostacyclin receptor or PPARδ.1,2,3 Carbaprostacyclin methyl ester is a more lipid soluble form of carbaprostacyclin. As a result, it may more readily enter cells to activate PPARδ. The biological activities of carbaprostacyclin methyl ester have not been studied. | [Uses]
Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin (HY-112322). | [References]
1. Aubert, J., Ailhaud, G., and Negrel, R. Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells FEBS Lett. 397(1),117-121(1996).
2. Armstrong, R.A., Lawrence, R.A., Jones, R.L., et al. Functional and ligand binding studies suggest heterogeneity of platelet prostacyclin receptors Br. J. Pharmacol. 97,657-668(1989).
3. Kurtz, M., Capobianco, E., Martínez, N., et al. Carbaprostacyclin, a PPARδ agonist, ameliorates excess lipid accumulation in diabetic rat placentas Life Sci. 86,781-790(2010). |
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