Identification | Back Directory | [Name]
3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID | [CAS]
696-22-0 | [Synonyms]
3-Methyl-5-pyrazolecarboxylic acid Pyrazole-3-carboxylic acid, 5-methyl- Pyrazole-5-carboxylic acid, 3-methyl- 3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 1H-Pyrazole-3-carboxylic acid, 5-Methyl- 5(or 3)-Methyl-pyrazole-3(or 5)-carboxylic Acid 5-Methyl-2H-pyrazole-3-carboxylic acid,hydrochloride 3-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE) InChI=1/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9 | [Molecular Formula]
C5H6N2O2 | [MDL Number]
MFCD00462235 | [MOL File]
696-22-0.mol | [Molecular Weight]
126.11 |
Hazard Information | Back Directory | [Definition]
ChEBI: 5-methyl-pyrazole-3-carboxylic acid is a memebr of the class of pyrazoles that is 1H-pyrazole with methyl and carboxylic acid group substituents at positions 5 and 3 respectively. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It derives from a hydride of a 1H-pyrazole. | [Synthesis]
General procedure for the synthesis of 3-methyl-1H-pyrazole-5-carboxylic acid from methyl 5-methyl-1H-pyrazole-3-carboxylate: 75 ml of methanol solution of 10.1 g (71.8 mmol) of methyl 5-methyl-1H-pyrazole-3-carboxylate was added to the reaction flask and stirred until complete dissolution. Subsequently, 150 ml of an aqueous solution containing 4.4 g (110 mmol) of sodium hydroxide was slowly added. The reaction mixture was heated to 50°C and kept at this temperature for 2 hours. After completion of the reaction, the pH of the reaction solution was adjusted to 2 with 2 M hydrochloric acid solution, at which point a solid precipitated. The precipitate was collected by filtration and the filter cake was washed with an appropriate amount of water. Finally, the filter cake was dried to give a white solid product 3-methyl-1H-pyrazole-5-carboxylic acid in 99.8% yield. | [References]
[1] Patent: CN105669556, 2016, A. Location in patent: Paragraph 0083; 0084; 0085 |
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