| Identification | Back Directory | [Name]
DCB | [CAS]
6971-97-7 | [Synonyms]
NSC 67224
DCB, 10 mM in DMSO
3,3'-DICHLOROBENZALDAZINE
3,3'-Dichlorobenzylideneazine
α,α'-Azinobis(m-chlorotoluene)
Benzaldehyde, m-chloro-, azine
1,2-Bis(3-chlorobenzylidene)hydrazine
(1E)-bis(3-chlorobenzylidene)hydrazine
3,3μ-Dichlorobenzaldazine, NSC 67224
1,1'-(Azinobismethylidyne)bis(3-chlorobenzene)
[(3-CHLOROPHENYL)METHYLENE]HYDRAZONE-3-CHLOROBENZALDEHYDE
Benzaldehyde, 3-chloro-, [(3-chlorophenyl)methylene]hydrazone
Benzaldehyde, 3-chloro-, 2-[(3-chlorophenyl)methylene]hydrazone | [Molecular Formula]
C14H10Cl2N2 | [MDL Number]
MFCD00556081 | [MOL File]
6971-97-7.mol | [Molecular Weight]
277.15 |
| Chemical Properties | Back Directory | [Melting point ]
40 °C | [Boiling point ]
387.8±42.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~6.8 mg/mL | [form ]
solid | [pka]
5.84±0.50(Predicted) | [color ]
yellow | [InChI]
1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+ | [InChIKey]
XMOVWXSCYLINBJ-BEQMOXJMSA-N | [SMILES]
Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1 |
| Hazard Information | Back Directory | [Uses]
DCB is an allosteric ligand for mGluR-5 (1). Regulates glutamate concentration however may induce neuronal damage through cerebral ischemia (2). | [Biological Activity]
Allosteric ligand for the metabotropic glutamate receptor mGlu 5 ; displays neutral modulation. Does not affect agonist-stimulated mGlu 5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB ([(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde ) and DMeOB ([(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde ). | [IC 50]
mGluR 5 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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