| Identification | Back Directory | [Name]
5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione | [CAS]
69849-33-8 | [Synonyms]
1-Propargyl-5-fluorouracil
5-Fluoro-1-propargyl-uracil
5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
5-Fluoro-1-(prop-2-yn-1-yl)pyrimidine -2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(2-propyn-1-yl)- | [Molecular Formula]
C7H5FN2O2 | [MDL Number]
MFCD18364451 | [MOL File]
69849-33-8.mol | [Molecular Weight]
168.13 |
| Chemical Properties | Back Directory | [Melting point ]
169-171 °C | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble1mg/mL, clear (warmed) | [form ]
powder | [pka]
7.63±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 1mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Biological Activity]
5-Fluoro-1-propargyl-uracil is a biologically inert precursora prodrug th at can be bioorthogonally activated to 5-fluorouracil iside a tumor th at has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells. |
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