| Identification | Back Directory | [Name]
Olivomycin | [CAS]
6988-58-5 | [Synonyms]
Olivomycin
olivomycin A
3'''-O-[3-C-Methyl-4-O-(2-methyl-1-oxopropyl)-2,6-dideoxy-α-L-arabino-hexopyranosyl]olivomycin D
D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-2,6-dideoxy-3-C-methyl-4-O-(2-methyl-1-oxopropyl)-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-h... | [Molecular Formula]
C58H84O26 | [MOL File]
6988-58-5.mol | [Molecular Weight]
1197.27 |
| Chemical Properties | Back Directory | [Melting point ]
160-165° | [alpha ]
D20 -36° (c = 0.5 in ethanol) | [Boiling point ]
782.67°C (rough estimate) | [density ]
1.1373 (rough estimate) | [refractive index ]
1.6500 (estimate) | [color ]
Yellow crystals |
| Hazard Information | Back Directory | [Definition]
ChEBI:Olivomycin A is an olivomycin and a secondary alpha-hydroxy ketone. It has a role as an antimicrobial agent. | [Safety Profile]
Poison by intraperitoneal andintravenous routes. | [Enzyme inhibitor]
These chromomycin-like antibiotics (FWOlivomycin-A = 1197.3 g/mol; CAS 6988-58-5) produced by Streptomyces olivoreticuli anthat bind to DNA in a base pair-specific manner, preferring Guanine:Cytosine pairs. The major component, olivimycin A, is a yellow solid that is insoluble in water and soluble in ethanol and chloroform. Target(s): DNA-directed DNA polymerase; DNA-directed RNA polymerase; EcoRI restriction endonuclease, or Type II site-specific deoxyribonuclease. |
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