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69981-39-1

69981-39-1 Structure

69981-39-1 Structure
IdentificationBack Directory
[Name]

Bis-Tos-(2-hydroxyethyl disulfide)
[CAS]

69981-39-1
[Synonyms]

Bis-Tos-(2-hydroxyethyl disulfide)
Bis-tosyl-(2-hydroxyethyl disulfide)
[Molecular Formula]

C18H22O6S4
[MDL Number]

MFCD28976689
[MOL File]

69981-39-1.mol
[Molecular Weight]

462.62
Chemical PropertiesBack Directory
[Melting point ]

69 °C(Solv: ethanol (64-17-5))
[Boiling point ]

625.6±50.0 °C(Predicted)
[density ]

1.360±0.06 g/cm3(Predicted)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Bis-Tos-(2-hydroxyethyl disulfide) contains a cleavable disulfide bond and two tosyl moieties. Tosyl is a good leaving group and can be replaces by a nucleophiles. The disulfide bond can be cleaved via reduction.
[Uses]

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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