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70006-24-5

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70006-24-5 Structure

70006-24-5 Structure
IdentificationBack Directory
[Name]

2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
[CAS]

70006-24-5
[Synonyms]

ABT 724
ABT 724 TRIHYDROCHLORIDE
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole
1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-
2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE
[Molecular Formula]

C17H19N5
[MDL Number]

MFCD08703101
[MOL File]

70006-24-5.mol
[Molecular Weight]

293.37
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[form ]

solid
[color ]

White
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P280-P302+P352-P362+P364
[HS Code ]

2933599590
Hazard InformationBack Directory
[Uses]

ABT 724 trihydrochloride is a potent dopamine D4 receptor agonist. ABT 724 is used in pharmacology systems for treating ocular disorders.
[Definition]

ChEBI: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole is a member of pyridines and a member of piperazines.
[Biological Activity]

Potent dopamine D 4 receptor partial agonist (EC 50 = 12.4 nM; 61% efficacy vs. dopamine). Has no agonist activity at D 2 receptors (EC 50 > 10 μ M). Selective in rats in vivo : produces penile erection following i.c.v. administration; increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. Displays minimal side effects.
Spectrum DetailBack Directory
[Spectrum Detail]

2-[[4-(2-PYRIDINYL)-1-PIPERAZINYL]METHYL]-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE(70006-24-5)1HNMR
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