| Identification | Back Directory | [Name]
Benzoic acid, 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methyl-, methyl ester | [CAS]
700870-56-0 | [Synonyms]
Benzoic acid, 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methyl-, methyl ester | [Molecular Formula]
C16H16O6 | [MOL File]
700870-56-0.mol | [Molecular Weight]
304.29 |
| Hazard Information | Back Directory | [Uses]
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2]. | [References]
[1] Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. DOI:10.1021/bc3003666
[2] Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625. DOI:10.1021/acs.jmedchem.8b01868 |
|
|