| Identification | Back Directory | [Name]
4-(4-HYDROXYPHENYL)BUTANOIC ACID | [CAS]
7021-11-6 | [Synonyms]
4-(4-HYDROXYPHENYL)B
P-HYDOROXYPHENYLBUTANOIC ACID
4-(4-HYDROXYPHENYL)BUTYRIC ACID
4-(4-HYDROXYPHENYL)BUTANOIC ACID | [Molecular Formula]
C10H12O3 | [MDL Number]
MFCD00033287 | [MOL File]
7021-11-6.mol | [Molecular Weight]
180.2 |
| Chemical Properties | Back Directory | [Melting point ]
110-111 °C | [Boiling point ]
128-200 °C(Press: 0.4 Torr) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), DMSO (slightly) | [form ]
Solid | [pka]
4.78±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
4-Carboxypropylphenol is a bacterial chlorophyll derivative. | [Synthesis]
4-(4-Methoxyphenyl)butyric acid (25g, 129mmol) was dissolved in 48% HBr (125ml) and AcOH (125ml). The resulting solution was heated at 150°C overnight. The resulting mixture was concentrated in vacuo and the residue was dissolved in EtOAc (500ml). The solution was washed with water (500ml), dried (MgSO4) and concentrated to give 4-(4-hydroxyphenyl)butanoic acid as a tan solid. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 509 - 513
[2] Journal of Natural Products, 2017, vol. 80, # 5, p. 1623 - 1630
[3] Organic Process Research and Development, 2004, vol. 8, # 4, p. 670 - 673
[4] Patent: EP2388247, 2011, A2. Location in patent: Page/Page column 12
[5] Patent: US2011/288133, 2011, A1. Location in patent: Page/Page column 10 |
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