| Identification | Back Directory | [Name]
BX-912 | [CAS]
702674-56-4 | [Synonyms]
BX 912
CS-339
BX912/BX-912
BX-912, >=98%
N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c
N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide
N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-
1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-
BX9121-PYRROLIDINECARBOXAMIDE,N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-
PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDIN-2-YLAMINO)-PHENYL)-AMIDE
BX-912
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-912
N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
BX912/BX-912
N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imid | [Molecular Formula]
C20H23BrN8O | [MDL Number]
MFCD10565925 | [MOL File]
702674-56-4.mol | [Molecular Weight]
471.35 |
| Chemical Properties | Back Directory | [density ]
1.596 | [storage temp. ]
-20°C | [solubility ]
≥23.55 mg/mL in DMSO; insoluble in H2O; ≥10.25 mg/mL in EtOH | [form ]
powder | [color ]
white to beige | [InChIKey]
DMMILYKXNCVKOJ-UHFFFAOYSA-N | [SMILES]
Brc1c(nc(nc1)Nc3cc(ccc3)NC(=O)N4CCCC4)NCCc2nc[nH]c2 |
| Safety Data | Back Directory | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC.1 BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM).2 It less effectively inhibits a panel of related serine-threonine kinases.2 BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.3,4,5 | [Uses]
A selective potent PDK-1 inhibitor with an IC50 of 12 nM. | [Definition]
ChEBI: N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas. | [target]
PDK-1 | [References]
[1] feldman ri1, wu jm, polokoff ma, kochanny mj, dinter h, zhu d, biroc sl, alicke b, bryant j, yuan s, buckman bo, lentz d, ferrer m, whitlow m, adler m, finster s, chang z, arnaiz do. novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. j biol chem. 2005 may 20;280(20):19867-74. epub 2005 mar 16. |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
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LETOPHARM LIMITED
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+86-21-5821 5861 |
| Website: |
www.letopharm.com |
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