| Identification | Back Directory | [Name]
1-Propanone, 1-(6-methoxy-1,3-benzodioxol-5-yl)- | [Synonyms]
Methyl kakuol
1-Propanone, 1-(6-methoxy-1,3-benzodioxol-5-yl)- | [MDL Number]
MFCD30608285 | [Molecular Weight]
208.21 |
| Hazard Information | Back Directory | [Uses]
Methyl kakuol shows agonistic activity against TRPA1 with an EC50 of 0.27 μM[1]. | [in vivo]
The maximum concentration (Cmax) of Methyl kakuol at a dose of 2 g/kg (containing 1156 μg/kg, 294 μg/kg, 452 μg/kg, 852 μg/kg asarinin, sesamin, methyl kakuol, and amide A, respectively) is 98.2 ng/mL[1]. | [IC 50]
TRPA1 | [References]
[1] Takashi Matsumoto, et al. In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix. Molecules. 2020 Sep DOI:10.3390/molecules25184283 |
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