| Identification | Back Directory | [Name]
2-hydroxy-4-Morpholinobenzaldehyde | [CAS]
70362-07-1 | [Synonyms]
2-hydroxy-4-Morpholinobenzaldehyde
Benzaldehyde, 2-hydroxy-4-(4-morpholinyl)- | [Molecular Formula]
C11H13NO3 | [MDL Number]
MFCD00228054 | [MOL File]
70362-07-1.mol | [Molecular Weight]
207.23 |
| Chemical Properties | Back Directory | [Boiling point ]
401.3±45.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 33 mg/ml,DMSO: 33 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml | [pka]
8.48±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate. It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ (IC50s = 2.8, 5.1, and 37 nM, respectively) but not p110α (IC50 = ~10 μM) or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2 (IC50s = >50 μM). It enhances radiation-induced cytotoxicity of HCT116 cells when used at a concentration of 100 μM. | [storage]
Store at -20°C |
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| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
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