| Identification | Back Directory | [Name]
CP 47497 | [CAS]
70434-82-1 | [Synonyms]
CP 47947
CP 47497
cis-3-(2-Hydroxy-4-(1,1-diMethylheptylphenyl)-cyclohexan-1-
2-[(1R,3S)-3-hydroxycyclohexyl]-5-(2-methyloctan-2-yl)phenol
rel-5-(1,1-Dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]phenol
rel-3α*-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]cyclohexane-1α*-ol
Phenol, 5-(1,1-dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-, rel- | [Molecular Formula]
C21H34O2 | [MOL File]
70434-82-1.mol | [Molecular Weight]
318.49 |
| Chemical Properties | Back Directory | [Boiling point ]
421.2±45.0 °C(Predicted) | [density ]
1.010±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
A crystalline solid | [pka]
10.25±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
CP 47,497 is a monophenol cannabimimetic compound that binds the central cannabinoid (CB1) receptor with a Ki value of 2.2 nM. It is equivalent in analgesic potency to Δ9-THC and exhibits other CB biological activities as well. | [Chemical Properties]
White Solid | [Uses]
A cannabinoid receptor ligand. | [Definition]
ChEBI: Phenol, 5-(1,1-dimethylheptyl)-2-[(1r,3s)-3-hydroxycyclohexyl]- is a ring assembly and an alkylbenzene. | [Biological Activity]
Potent CB 1 receptor agonist (K i = 2.2 nM). Display 3-28-fold > potency than Δ 9 -THC . Exhibits analgesic, motor depressant, anticonvulsant and hypothermic effects in vivo . | [References]
[1] JOHN W. HUFFMAN . Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940[J]. Bioorganic & Medicinal Chemistry, 2008, 16 1: Pages 322-335. DOI: 10.1016/j.bmc.2007.09.033
[2] L S MELVIN. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.[J]. Molecular Pharmacology, 1993, 44 5: 1008-1015.
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