| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl- | [CAS]
70460-58-1 | [Synonyms]
5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methylchroman-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl- | [Molecular Formula]
C16H14O5 | [MOL File]
70460-58-1.mol | [Molecular Weight]
286.28 |
| Hazard Information | Back Directory | [Uses]
(rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 μg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β[1]. | [References]
[1] Sucahyo A, et al. Flavanones from ethyl acetate fraction of Caesalpinia sappan heartwood as anti-inflammatory and antioxidant: Isolation, in-vitro, and in-silico approach[C]//AIP Conference Proceedings. AIP Publishing, 2024, 3055(1). |
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