| Identification | Back Directory | [Name]
Olean-12-ene-3,16,21,22,23,28-hexol, 21-[(2E)-2-methyl-2-butenoate], (3β,4β,16α,21β,22α)- | [CAS]
7047-43-0 | [Synonyms]
Protoescigenin 21-tiglate
Olean-12-ene-3,16,21,22,23,28-hexol, 21-[(2E)-2-methyl-2-butenoate], (3β,4β,16α,21β,22α)- | [Molecular Formula]
C35H56O7 | [MOL File]
7047-43-0.mol | [Molecular Weight]
588.83 |
| Hazard Information | Back Directory | [Uses]
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively[1]. | [References]
[1] Yang Y, et al. 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro[J]. RSC advances, 2019, 9(54): 31758-31772. |
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