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704888-90-4

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704888-90-4 Structure

704888-90-4 Structure
IdentificationBack Directory
[Name]

ARP100
[CAS]

704888-90-4
[Synonyms]

ARP100
MMP-2 Inhibitor III
N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide
N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-
[Molecular Formula]

C17H20N2O5S
[MDL Number]

MFCD09971105
[MOL File]

704888-90-4.mol
[Molecular Weight]

364.42
Questions And AnswerBack Directory
[Uses]

ARP 100 is a potent, dual inhibitor of MMP-12/MMP-13 targets, which are a family of zinc dependent endopeptidases known to play key roles in extracellular matrix (ECM) breakdown disorders, such as the two main forms of arthritis, rheumatoid arthritis (RA) and osteoarthritis (OA).
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at +4°C
[solubility ]

Soluble at 100mM in DMSO
[form ]

Solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Spectrum DetailBack Directory
[Spectrum Detail]

ARP100(704888-90-4)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Selective inhibitor of MMP-2 (IC 50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC 50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
[IC 50]

MMP-2: 12 nM (IC50); MMP-9: 0.2 μM (IC50); MMP-3: 4.5 μM (IC50); MMP-1: >50 μM (IC50); MMP-7: >50 μM (IC50)
[storage]

Desiccate at -20°C
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