| Identification | Back Directory | [Name]
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE | [CAS]
70641-51-9 | [Synonyms]
Ro 14-5243
ET-18-OCH?
ET-18-OCH3
EDELFOSINE
NSC 324368
NSC 343649
SN-ET-18-OCH3
2-O-METHYL PAF C-18
18:0-1:0 DIETHER PC
innersalt,4-oxide,(+-)-hydroxide
ET-18-OCH - CAS 70641-51-9 - Calbiochem
1-Octadecyl-2-methylglycero-3-phosphorylcholine
rac-1-octadecyl-2-methoxyglycero-3-phosphocholine
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1-O-OCTADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
Racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine
(2-methoxy-3-stearyloxy-propyl) 2-(trimethylammonio)ethyl phosphate
(2-methoxy-3-octadecoxypropyl) 2-(trimethylazaniumyl)ethyl phosphate
(2-methoxy-3-octadecoxy-propyl) 2-(trimethylazaniumyl)ethyl phosphate
Edelfosine, ALP, Ro 14-5243, ET-18-OMe, ET 18-OCH3, NSC 324368, NSC 343649
3,5,9-trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-7-methoxy-n,n,n-trimethyl
4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-Trioxa-4-phosphaheptacosan-1-aminium 4-oxide
3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide | [Molecular Formula]
C27H58NO6P | [MDL Number]
MFCD00063527 | [MOL File]
70641-51-9.mol | [Molecular Weight]
523.74 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
ethanol: 15 mg/mL at 45 °C, soluble | [form ]
waxy solid | [pka]
1.200±0.50(predicted) | [color ]
white | [Water Solubility ]
Soluble to 20 mM in water | [InChI]
1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3 | [InChIKey]
MHFRGQHAERHWKZ-UHFFFAOYSA-N | [SMILES]
CCCCCCCCCCCCCCCCCCOCC(COP([O-])(=O)OCC[N+](C)(C)C)OC |
| Hazard Information | Back Directory | [Uses]
Edelfosine has been used to treat human lung carcinoma A549 cells and study its effects on tuftelin 1 (TUFT1) expression. It is also used to evaluate the cell growth of MCF-7/M cells. | [Definition]
ChEBI: 1-octadecyl-2-methylglycero-3-phosphocholine is a glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively. | [General Description]
Edelfosine has anti-inflammatory, anti-autoimmune, antiparasitic and anti-viral properties. It stimulates eryptosis by cell shrinkage and cell membrane scrambling. | [Biochem/physiol Actions]
Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity. The compound induces apoptosis in a variety of cancer cells. Edelfosine accumulates in the cell membrane, where it alters lipid composition and induces the co-clustering of lipid rafts and Fas/CD95 death receptor. | [storage]
Store at -20°C |
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