| Identification | Back Directory | [Name]
2,2-DIOXO-1,3-DIHYDROBENZO[C]THIOPHENE-5YL AMINE | [CAS]
70654-85-2 | [Synonyms]
2,2-dioxo-1,3-dihydro-2-benzothiophen-5-amine
2,2-Dioxo-1,3-dihydrobenzo[c]thiophen-5-ylamine
5-Amino-1,3-dihydro-2λ6-benzothiophene-2,2-dione
2,2-DIOXO-1,3-DIHYDROBENZO[C]THIOPHENE-5YL AMINE
5-Amino-1,3-dihydrobenzo[c]thiophene 2,2-dioxide
5-Amino-2,3-dihydro-1H-benzo[c]thiophene-2,2-dione
Benzo[c]thiophen-5-amine, 1,3-dihydro-, 2,2-dioxide
5-amino-1,3-dihydro-2lambda6-benzothiophene-2,2-dione
2,2-Dioxo-1,3-dihydrobenzo[c]thiophene-5yl amine, Tech. | [Molecular Formula]
C8H9NO2S | [MDL Number]
MFCD00178261 | [MOL File]
70654-85-2.mol | [Molecular Weight]
183.23 |
| Chemical Properties | Back Directory | [Melting point ]
186 °C | [Boiling point ]
483.4±45.0 °C(Predicted) | [density ]
1.438±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
3.48±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure: 5-nitro-1,3-dihydrobenzo[c]thiophene 2,2-dioxide (Compound 86.4, 0.12 g, 0.56 mmol, 1.0 eq.) was added to a suspension of 10% Pd/C (0.03 g) in methanol (3.0 mL). The suspension was purged with hydrogen (H2) gas for 1 hour. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford 5-amino-1,3-dihydrobenzo[c]thiophene 2,2-dioxide (Compound 86.5, 0.08 g, 77.5% yield). Mass spectrum (electrospray ionization): m/z 184.1 [M + H]+. | [References]
[1] Russian Chemical Bulletin, 2005, vol. 54, # 2, p. 437 - 440
[2] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 1028; 1035; 1036
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 8, p. 2399 - 2406 |
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