| Identification | Back Directory | [Name]
2-Deoxy-2-fluoro-L-fucose | [CAS]
70763-62-1 | [Synonyms]
2-Deoxy-2-fluoro-L-fucose
2,6-dideoxy-2-fluoro-L-Galactose
L-Galactose, 2,6-dideoxy-2-fluoro-
2-Deoxy-2-fluoro-L-fucose, Min. 98%
(2S,3R,4R,5S)-2-Fluoro-3,4,5-trihydroxyhexanal
(3S,4R,5S,6S)-3-Fluoro-6-methyl-tetrahydropyran-2,4,5-triol | [Molecular Formula]
C6H11FO4 | [MDL Number]
MFCD08457748 | [MOL File]
70763-62-1.mol | [Molecular Weight]
166.15 |
| Chemical Properties | Back Directory | [Boiling point ]
386.5±42.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [pka]
12.70±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C6H11FO4/c1-3(9)5(10)6(11)4(7)2-8/h2-6,9-11H,1H3/t3-,4+,5+,6-/m0/s1 | [InChIKey]
SQTFKIKSQNCWGJ-KCDKBNATSA-N | [SMILES]
O=C[C@@H](F)[C@@H]([C@@H]([C@H](C)O)O)O |
| Hazard Information | Back Directory | [Uses]
2-Deoxy-2-fluoro-L-fucose is a useful compound in the area of cancer treatment. as it has been used in adoptive cell therapy. | [Uses]
Fucose is a deoxyhexose that is present in many organisms. Fucose-containing glycans, generated by fucosyltransferase using GDP-fucose, have roles in cell signaling, cell-cell interactions, and blood properties. 2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases. Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 μM). | [storage]
Store at -20°C |
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