| Identification | Back Directory | [Name]
N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride | [CAS]
7082-21-5 | [Synonyms]
Mictrol
Terodilin hydrochloride
Terodiline hydrochloride
Terodiline hydrochloride >=98% (HPLC), solid
N-(4,4-diphenylbutan-2-yl)-2-methyl-propan-2-amine hydrochloride
N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride
Bicor, N-(1,1-Dimethylethyl)-alpha-methyl-gamma-phenylbenzenepropamine hydrochloride | [Molecular Formula]
C20H28ClN | [MDL Number]
MFCD00941402 | [MOL File]
7082-21-5.mol |
| Hazard Information | Back Directory | [Uses]
Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1]. | [Definition]
ChEBI:Terodiline hydrochloride is a diarylmethane. | [Biological Activity]
Terodiline hydrochloride is a non-selective calcium channel antagonist with anticholinergic and vasodilatory activity.''Terodiline is known to increase corrected QT interval (QTc) and decrease resting heart rate in elderly patients. Furthermoreterodiline hydrochloride has been linked to cardiac arrhythmias1. | [in vivo]
Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1]. | Animal Model: | Fmale or male Hartley guinea pigs (200-600 g)[1] | | Dosage: | 80 mg/kg | | Administration: | Administered S.C. | | Result: | Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal. |
| [storage]
Store at -20°C | [References]
[1] Noronha-Blob L, et al. (+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201(2-3):135-42. DOI:10.1016/0014-2999(91)90336-o |
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