| Identification | Back Directory | [Name]
prifuroline | [CAS]
70833-07-7 | [Synonyms]
prifuroline
3-(Benzofuran-2-yl)-3,4-dihydro-N,N-dimethyl-2H-pyrrol-5-amine
3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine
2H-Pyrrol-5-amine, 3-(2-benzofuranyl)-3,4-dihydro-N,N-dimethyl-
3-(benzofuran-2-yl)-N,N-dimethyl-3,4-dihydro-2H-pyrrol-5-amine(WXC06062) | [Molecular Formula]
C14H16N2O | [MDL Number]
MFCD00864755 | [MOL File]
70833-07-7.mol | [Molecular Weight]
228.29 |
| Chemical Properties | Back Directory | [Boiling point ]
383.8±31.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
8.55±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Prifuroline is an antiarrhythmic agent. | [in vivo]
Prifuroline is an antiarrhythmic agent. Prifuroline dose-dependently antagonizes the arrhythmogenic action of aconitine in rats, when administered either intravenously (5, 10 or 20 mg/kg) or intraduodenally (10, 20 or 50 mg/kg). Prifuroline also diminishes ventricular susceptibility to electrical stimulation in open-chest rats. The arrhythmias induced in dogs by coronary artery ligation are markedly antagonized by Prifuroline after doses of 5 and 10 mg/kg i.v. or 30 mg/kg intraduodenally. The duration of its antiarrhythmic activity in this model of arrhythmias in conscious dogs is much longer after intraduodenal than after i.v. administration[1]. | [References]
[1] Benharkate M, et al. Antiarrhythmic and hemodynamic effects of prifuroline. Arzneimittelforschung. 1986 Dec;36(12):1761-7. PMID:3566836 |
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