| Identification | Back Directory | [Name]
Benzoic acid, 4-[[4-[4-(acetylamino)phenyl]-2-thiazolyl]amino]-2-hydroxy- | [CAS]
708992-34-1 | [Synonyms]
SIRT5 inhibitor 4
Benzoic acid, 4-[[4-[4-(acetylamino)phenyl]-2-thiazolyl]amino]-2-hydroxy- | [Molecular Formula]
C18H15N3O4S | [MOL File]
708992-34-1.mol | [Molecular Weight]
369.39 |
| Hazard Information | Back Directory | [Uses]
SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1]. | [IC 50]
SIRT5: 26.4 μM (IC50); SIRT1: ＞400 μM (IC50); SIRT2: ＞400 μM (IC50); SIRT3: ＞400 μM (IC50); SIRT6: ＞400 μM (IC50); SIRT7: ＞400 μM (IC50) | [References]
[1] Han LY, et, al. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors. Eur.J.Med.Chem.2022 Jul 22, 114623 DOI:10.1016/j.ejmech.2022.114623 |
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