| Identification | Back Directory | [Name]
ETILEFRINE-D5 | [CAS]
709-55-7 | [Synonyms]
S 40032
S 40032-7
Etilefrin
Aids001656
Aids-001656
Etilephrine
Etilefrin-d5
Etiladrianol
dl-Etilefrin
ETILEFRINE-D5
(+-)-Etilefrin
Ethylphenylephrine
Racemic etilefrine
Etilefrinhydrochlorid
N-Ethylnorphenylephrine
943-17-9 (Hydrochloride)
Ethylephrine hydrochloride
Etilefrin
DISCONTINUED, offer E932950
m-[2-(Ethylamino)-1-hydroxyethyl]phenol
3-[2-(ethylamino)-1-hydroxyethyl]phenol
1-(3-Hydroxyphenyl)-2-(ethylamino)ethanol
α-(m-Hydroxyphenyl)-β-(ethylamino)ethanol
m-Hydroxy-α-(ethylaminomethyl)benzyl alcohol
α-[(Ethylamino)methyl]-m-hydroxybenzyl alcohol
Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-
Benzyl alcohol, α-[(ethylamino)methyl]-m-hydroxy- (6CI, 8CI)
.alpha.-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride
Benzenemethanol, .alpha-[(ethylamino)methyl]-3-hydroxy-, hydrochloride | [EINECS(EC#)]
211-910-4 | [Molecular Formula]
C10H15NO2 | [MDL Number]
MFCD08063567 | [MOL File]
709-55-7.mol | [Molecular Weight]
181.23 |
| Chemical Properties | Back Directory | [Melting point ]
147-148° | [Boiling point ]
314.35°C (rough estimate) | [density ]
1.0918 (rough estimate) | [refractive index ]
1.5464 (estimate) | [pka]
9.81±0.10(Predicted) | [LogP]
3.2 at 25℃ and pH5.5 |
| Hazard Information | Back Directory | [Originator]
Circupon,Troponwerke,W. Germany | [Uses]
Etilefrin is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension. | [Uses]
ETILEFRINE-D5 is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
| [Definition]
ChEBI:3-[2-(ethylamino)-1-hydroxyethyl]phenol is a member of phenols. | [Manufacturing Process]
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C. | [Therapeutic Function]
Tranquilizer |
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