| Identification | Back Directory | [Name]
Benzenemethanamine, 4-bromo-N-methyl-N-2-propyn-1-yl- | [CAS]
709-85-3 | [Synonyms]
PYCR1-IN-1
N-(4-bromobenzyl)-N-methylprop-2-yn-1-amine
(4-bromophenyl)methyl](methyl)(prop-2-yn-1-yl)amine
Benzenemethanamine, 4-bromo-N-methyl-N-2-propyn-1-yl- | [Molecular Formula]
C11H12BrN | [MDL Number]
MFCD14645242 | [MOL File]
709-85-3.mol | [Molecular Weight]
238.12 |
| Chemical Properties | Back Directory | [Boiling point ]
287.0±20.0 °C(Predicted) | [density ]
1.330±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
6.27±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 μM. PYCR1-IN-1 has anticancer effects[1]. | [References]
[1] Kirsty Milne, et al. A fragment-like approach to PYCR1 inhibition. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2626-2631. DOI:10.1016/j.bmcl.2019.07.047 |
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