| Identification | Back Directory | [Name]
KYOTORPHIN | [CAS]
70904-56-2 | [Synonyms]
YR
TYR-ARG
KYOTORPHIN
Tyr-Arg-OH
Kiotorphin
H-TYR-ARG-OH
L-Tyr-L-Arg-OH
kyotorphin acetate
KYOTORPHIN, BOVINE
L-Tyrosyl-L-arginine
L-Arginine, L-tyrosyl-
Nα-(L-Tyrosyl)-L-arginine
KYOTORPHIN ACETATE SALT, H-TYR-ARG-OH ACETATE SALT
(S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-5-guanidinopentanoic acid
(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-guanidino-valeric acid
(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
(2S)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanoic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C15H23N5O4 | [MDL Number]
MFCD00076700 | [MOL File]
70904-56-2.mol | [Molecular Weight]
337.37 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [pka]
3.09±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear | [InChIKey]
KTMKVRFTDZZFFE-FXMYHANSSA-N | [SMILES]
NC(NCCC[C@@H](C(O)=O)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=N.C |
| Hazard Information | Back Directory | [Definition]
ChEBI: Tyr-Arg is a dipeptide composed of L-tyrosine and L-arginine joined by a peptide linkage. It is a conjugate base of a L-tyrosiniumyl-L-arginine(1+). | [Biological Activity]
Kyotorphin is a neuroactive dipeptide (Tyr-Arg) shown to have analgesicneuroprotectiveand neuromodulatory properties. It is synthesized in nerve terminals and found in the brain and in cerebro-spinal fluid (CSF). Kyotorphin indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). CSF levels are lower in patients with persistent pain and in patients with Alzheimer′s disease. |
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