| Identification | Back Directory | [Name]
2-AMINO-5-BROMO-NICOTINONITRILE | [CAS]
709652-82-4 | [Synonyms]
2-AMINO-5-BROMO-NICOTINONITRILE
2-AMino-5-broMo-3-cyanopyridine
2-Amino-5-bromo-3-cyanopyridine 97%
2-Amino-5-bromo-nicotinonitrile ,97%
2-Amino-5-bromo-3-pyridinecarbonitrile
3-Pyridinecarbonitrile, 2-amino-5-bromo-
2-AMINO-5-BROMO2-AMINO-5-BROMO-NICOTINONITRILE-NICOTINONITRILE | [Molecular Formula]
C6H4BrN3 | [MDL Number]
MFCD08688591 | [MOL File]
709652-82-4.mol | [Molecular Weight]
198.02 |
| Chemical Properties | Back Directory | [Boiling point ]
286.1±40.0 °C(Predicted) | [density ]
1.80±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
0.84±0.49(Predicted) | [color ]
Faint beige | [InChI]
InChI=1S/C6H4BrN3/c7-5-1-4(2-8)6(9)10-3-5/h1,3H,(H2,9,10) | [InChIKey]
UJKZMLZIIIGCMI-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(Br)C=C1C#N |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
25-37/38-41-20/21/22 | [Safety Statements ]
26-36-45-36/37-24/25 | [RIDADR ]
2811 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29333990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light brown solid | [Synthesis]
General procedure for the synthesis of 2-amino-5-bromopyridine-3-carbonitrile from 2-amino-3-cyanopyridine:
Example 1; 2-Amino-5-bromopyridine-3-carbonitrile (2); 2-Amino-3-cyanopyridine (0.56 g, 4.6 mmol) was dissolved in 10 mL of acetic acid followed by the addition of 1 equivalent of sodium carbonate. Then, 1.1 equivalents of bromine was added slowly and the reaction mixture was stirred at room temperature for 30 min. An orange precipitate was formed during the reaction and after filtration, the target compound 2 was obtained in quantitative yield.The compound can be used directly in subsequent reactions without further purification. | [References]
[1] Patent: WO2007/59219, 2007, A1. Location in patent: Page/Page column 54
[2] Chemical Papers, 2018, vol. 72, # 12, p. 2965 - 2972
[3] Patent: WO2013/29548, 2013, A1. Location in patent: Page/Page column 87
[4] Patent: US2014/179675, 2014, A1. Location in patent: Paragraph 0841
[5] Patent: US2016/311772, 2016, A1. Location in patent: Paragraph 1260-1263 |
|
|