70981-96-3

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70981-96-3 Structure

Identification	Back Directory
[Name] 15(S)-HPETE
[CAS] 70981-96-3
[Synonyms] 15(S)-HPETE 15(S)-HpETE Lipid Maps MS Standard 15-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid 15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraeno 15(S)-HYDROPEROXY-(5Z,8Z,11Z,13E)-EICOS ATETRAENOIC 15(S)-HYDROPEROXYEICOSA-5Z,8Z,11Z,13E-TETRAENOIC ACID 15(S)-HYDROPEROXY-(5Z,8Z,11Z,13E)-EICOSATETRAENOIC ACID (S-(E,Z,Z,Z))-15-Hydroperoxy-5,8,11,13-eicosatetraenoic acid 5,8,11,13-Eicosatetraenoic acid, 15-hydroperoxy-, (S-(E,Z,Z,Z))- 5,8,11,13-Eicosatetraenoic acid, 15-hydroperoxy-, (5Z,8Z,11Z,13E,15S)- 15(S)-Hydroperoxy-5(Z),8(Z),11(Z),13(E)-eicosatetraenoic acid [15(S)-HPETE] 15(S)-HYDROPEROXY-(5Z,8Z,11Z,13E)-EICOSATETRAENOIC ACID (2MG/ML ETHANOL SOLUTION)
[EINECS(EC#)] 633-223-2
[Molecular Formula] C20H32O4
[MDL Number] MFCD00063577
[MOL File] 70981-96-3.mol
[Molecular Weight] 336.47

Chemical Properties	Back Directory
[Fp ] 14 °C
[storage temp. ] −70°C
[solubility ] 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
[form ] Liquid
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Uses] 15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 or reduced to 15(S)-HETE by peroxidases. 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1. 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.
[Uses] 15(S)-HPETE is a primary metabolite of arachidonic acid shown to inhibit arachidonic acid induced platelet aggregation.
[Definition] ChEBI: The (S)-enantiomer of 15-HPETE.
[IC 50] c-Fos; c-Jun
[storage] Store at -80°C, protect from light

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