| Identification | Back Directory | [Name]
GSK-3 Inhibitor IX, Control, MeBIO | [CAS]
710323-61-8 | [Synonyms]
GSK-3 Inhibitor IX, Control, MeBIO
GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem
2H-Indol-2-one, 6-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-1-methyl- | [Molecular Formula]
C17H12BrN3O2 | [MDL Number]
MFCD09037537 | [MOL File]
710323-61-8.mol | [Molecular Weight]
370.2 |
| Chemical Properties | Back Directory | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 10mg/mL | [form ]
Dark red solid | [color ]
dark red | [InChI]
1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,15,19H,1H3/b16-14- | [InChIKey]
ATNXSIPNXWSMRK-PEZBUJJGSA-N | [SMILES]
Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2C |
| Hazard Information | Back Directory | [Uses]
A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO that serves as a relevant kinase inactive control (IC50 >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties. | [General Description]
A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC50 >92 μM for Cdk1/cyclin B, >100 μM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties. | [Biochem/physiol Actions]
Cell permeable: yes |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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