| Identification | Back Directory | [Name]
N-cyclohexyl-N'-(2-methyl-4-quinolineyl)-N''-thiazol-2-ylguanidine monohydrochloride | [CAS]
71080-06-3 | [Synonyms]
N-cyclohexyl-N'-(2-methyl-4-quinolineyl)-N''-thiazol-2-ylguanidine monohydrochloride | [EINECS(EC#)]
275-185-6 | [Molecular Formula]
C20H24ClN5S | [MOL File]
71080-06-3.mol | [Molecular Weight]
401.956 |
| Hazard Information | Back Directory | [Uses]
Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine (HY-100125). Timegadine hydrochloride is an orally active inhibitor for COX and lipo-oxygenase, that inhibits COX in washed rabbit platelets and rat brain with IC50 of 5 nM and 20 μM, inhibits lipo-oxygenase in in horse and washed rabbit platelets with IC50 of 100 μM. Timegadine hydrochloride exhibits anti-arthritis activity[1]. | [References]
[1] George S, et al. The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug. Br J Clin Pharmacol. 1983 Apr;15(4):495-8. DOI:10.1111/j.1365-2125.1983.tb01537.x
[2] Ahnfelt-R?nne I, et al. A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation. Biochem Pharmacol. 1980 Dec;29(2 DOI:10.1016/0006-2952(80)90301-9 |
|
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|