| Identification | Back Directory | [Name]
pinane-thromboxane A2 | [CAS]
71154-83-1 | [Synonyms]
OHJIHGVLRDHSDV-PUYXBYOHSA-N
5-Heptenoic acid, 7-[(1S,2R,3R,5S)-3-[(1E,3R)-3-hydroxy-1-octen-1-yl]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)-
(1S-(1alpha,2beta(Z),3alpha(1E,3S*),5alpha))-7-(3-(3-Hydroxy-1-octenyl)-6,6-dimethylbicyclo(3.1.1)hept-2-yl)-5-heptenoic acid | [Molecular Formula]
C24H40O3 | [MOL File]
71154-83-1.mol | [Molecular Weight]
376.57 |
| Hazard Information | Back Directory | [Description]
15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 (PTA2; ). 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM).1 It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.2 | [Uses]
15(R)-PTA2 (15(R)-Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15(R)-PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15(R)-PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase[1]. | [storage]
Store at -20°C | [References]
1. Caton, M.P.L., Stuttle, K.A.J., Tuffin, D.P., et al. Comparative action of carbocyclic thromboxane A2 stereoisomers on platelets Eur. J. Med. Chem. 35(12),1099-1107(2000).
2. Bennett, A., and Sanger, G.J. Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle Br. J. Pharmacol. 77(4),591-596(1982). |
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