| Identification | Back Directory | [Name]
Mcl1-IN-1 | [CAS]
713492-66-1 | [Synonyms]
CS-1222
Mcl1-IN-1
Mcl1 inhibitor 1
2-[2-[(5-Chloro-8-hydroxy-7-quinolinyl)(2-pyridinylamino)methyl]phenoxy]acetic acid
Acetic acid, 2-[2-[(5-chloro-8-hydroxy-7-quinolinyl)(2-pyridinylamino)methyl]phenoxy]- | [Molecular Formula]
C23H18ClN3O4 | [MDL Number]
MFCD06000335 | [MOL File]
713492-66-1.mol | [Molecular Weight]
435.86 |
| Chemical Properties | Back Directory | [Boiling point ]
681.6±55.0 °C(Predicted) | [density ]
1.455±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 50 mg/mL (114.72 mM) | [form ]
Solid | [pka]
3.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mcl1-IN-1 is a potent and selective inhibitor of the apoptosis regulating proteins Mcl-1. | [Uses]
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 μM). | [IC 50]
Mcl-1: 2.4 μM (IC50) | [References]
[1] Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. DOI:10.1016/j.bmc.2013.08.017 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
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