| Identification | Back Directory | [Name]
TOCAINIDE | [CAS]
71395-14-7 | [Synonyms]
Taquidil
Einecs 275-361-2
(±)-Form hydrochloride
Tocainide (+-)-form hydrochloride
2-Amino-2',6'-propionoxylidide hydrochloride
(1)-2-Amino-N-(2,6-dimethylphenyl)propionamide hydrochloride
(±)-2-amino-N-(2,6-dimethylphenyl)propionamide hydrochloride
rac-(R*)-2-Amino-N-(2,6-dimethylphenyl)propanamide·hydrochloride | [EINECS(EC#)]
275-361-2 | [Molecular Formula]
C11H16N2O | [MDL Number]
MFCD00072010 | [MOL File]
71395-14-7.mol | [Molecular Weight]
192.26 |
| Hazard Information | Back Directory | [Uses]
Antiarrhythmic;Na+ channel inhibitor | [Biological Activity]
Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine)used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.''Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic. | [in vivo]
Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1]. | [storage]
Store at -20°C |
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