| Identification | Back Directory | [Name]
3-CYANO-5-NITROINDOLE | [CAS]
7147-14-0 | [Synonyms]
3-CYANO-5-NITROINDOLE
5-Nitroindole-3-carbonitrile
1H-Indole-3-carbonitrile, 5-nitro- | [Molecular Formula]
C9H5N3O2 | [MDL Number]
MFCD02090219 | [MOL File]
7147-14-0.mol | [Molecular Weight]
187.15 |
| Hazard Information | Back Directory | [Uses]
3-Cyano-5-nitroindole is mainly used in pharmaceutical synthesis and organic experiments.
| [Synthesis]
GENERAL METHOD: A mixture of CuI (0.6 mmol), 5-nitroindole (0.5 mmol), and phenylacetonitrile (0.6 mmol) in DMF (3.0 mL) was placed in air and reacted with stirring for 34 h at 100 °C, followed by cooling to room temperature. Upon completion of the reaction, the reaction mixture was quenched with 10 mL of water followed by extraction with dichloromethane (DCM, 3 x 10 mL). The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate (MgSO?). Finally, the solution was concentrated under reduced pressure and purified by column chromatography to afford the target product 5-nitroindole-3-carbonitrile. | [References]
[1] Tetrahedron, 2013, vol. 69, # 21, p. 4236 - 4240 |
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| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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