| Identification | Back Directory | [Name]
BUTTPARK 182\12-94 | [CAS]
7150-23-4 | [Synonyms]
JBSNF-000088
BUTTPARK 182\12-94
6-Methoxynicotinamide
JBSNF-000088
(JBSNF000088
6-methoxy-3-pyridinecarboxamide
6-METHOXYPYRIDINE-3-CARBOXAMIDE
3-PYRIDINECARBOXAMIDE, 6-METHOXY- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C7H8N2O2 | [MDL Number]
MFCD00229166 | [MOL File]
7150-23-4.mol | [Molecular Weight]
152.15 |
| Chemical Properties | Back Directory | [Melting point ]
178-180°C | [Boiling point ]
301.6±22.0 °C(Predicted) | [density ]
1.213±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.17±0.50(Predicted) | [color ]
Off-White to Pale Beige | [InChI]
InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10) | [InChIKey]
KXDSMFBEVSJYRF-UHFFFAOYSA-N | [SMILES]
C1=NC(OC)=CC=C1C(N)=O |
| Hazard Information | Back Directory | [Description]
JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells. | [Uses]
6-Methoxynicotinamide (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO).
| [Biological Activity]
JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM. | [in vitro]
JBSNF-000088 (6-Methoxynicotinamide) has IC 50 values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells. | [target]
| Target | Value | hNNMT
(Cell-free assay) | 1.8 μM | mkNNM
(Cell-free assay) | 2.8 μM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> mNNMT
(Cell-free assay) 5.0 μM |
| [storage]
Store at -20°C |
|
| Company Name: |
InvivoChem Gold
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|