| Identification | Back Directory | [Name]
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE | [CAS]
71774-13-5 | [Synonyms]
cAMPS-Sp
(S)-Adenosine
Triethylammoniumsalt
camps,sp-isomer,teasalt
ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate]
Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
(S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM
adenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-camps),sodiumsalt
ADENOSINE3,5-CYCLICMONOPHOSPHOTHIOATESP-ISOMERTRIETHYLAMMONIUMSALT,HIGHPURITY | [Molecular Formula]
C10H12N5O5PS | [MDL Number]
MFCD01459901 | [MOL File]
71774-13-5.mol | [Molecular Weight]
345.27 |
| Chemical Properties | Back Directory | [Boiling point ]
648.0±65.0 °C(predicted) | [density ]
2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
water: 20 mg/mL | [form ]
crystalline solid | [pka]
-0.55±0.60(predicted) | [Water Solubility ]
water: 20mg/mL |
| Hazard Information | Back Directory | [Uses]
(S)-Adenosine, cyclic 3'',5''-(hydrogenphosphorothioate) triethylammonium is an activator of PKA. | [Definition]
ChEBI: (Sp)-cAMPS is a nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Sp-stereoisomer). It has a role as a protein kinase agonist. It is a member of purines and a nucleoside 3',5'-cyclic phosphorothioate. It is functionally related to a 3',5'-cyclic AMP. | [Biological Activity]
Cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor. | [in vivo]
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals[5]. | [IC 50]
PKA I; PKA II; PDE3A: 47.6 μM (Ki); PDE10 GAF domain: 50 μM (EC50) |
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