| Identification | Back Directory | [Name]
monactin | [CAS]
7182-54-9 | [Synonyms]
monactin
5-deMethyl-5-ethylnonactin, AKD 1B
4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5-ethyl-2,11,14,20,23,29,32-heptamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- | [Molecular Formula]
C41H66O12 | [MDL Number]
MFCD11111612 | [MOL File]
7182-54-9.mol | [Molecular Weight]
750.96 |
| Hazard Information | Back Directory | [Uses]
Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-γ. | [in vivo]
Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1]. |
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Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
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