| Identification | Back Directory | [Name]
Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) | [CAS]
71822-19-0 | [Synonyms]
Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) | [Molecular Formula]
C9H13F3N2O7 | [MOL File]
71822-19-0.mol | [Molecular Weight]
318.21 |
| Hazard Information | Back Directory | [Description]
γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.1 It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 μM, respectively).2 γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 μmol, i.c.v., respectively).3 | [References]
1. Crunelli, S., Forda, S., and Kelly, J.S. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus J. Physiol. 341,627-640(1983).
2. Raigorodsky, G., and Urca, G. Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartate Eur. J. Pharmacol. 182(1),37-47(1990).
3. Croucher, M.J., Collins, J.F., and Meldrum, B.S. Anticonvulsant action of excitatory amino acid antagonists Science 216(4548),899-901(1982). |
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