| Identification | Back Directory | [Name]
CATHEPSIN S | [CAS]
71965-46-3 | [Synonyms]
CTSS
MGC3886
FLJ50259
CATHEPSIN S
EC 3.4.22.27
Cathepsin S Active human
CATHEPSIN S, BOVINE SPLEEN
Cathepsin S from Human, recombinant
Recombinant Human Cathepsin S/CTSS Protein, His Tag
Recombinant Mouse Cathepsin-S/Ctss Protein, His Tag | [MDL Number]
MFCD02264373 |
| Hazard Information | Back Directory | [Uses]
Active human cathepsin S is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin S has been used in a study to assess the pathogenesis of Alzheimer′s disease. Active human cathepsin S has also been used in a study to investigate the optimization of selectivity of Azepanone-based inhibitors. | [General Description]
Human cathepsin S (GenBank Accession No. NM_004079.3), CD33 signal peptide(amino acids 1-16) + cathepsin S (amino acids 17-331), with C-terminal HIS tag, MW = 37 kDa, expressed in FreeStyle 293-F cells. | [Biological Activity]
Cathepsin Sas a lysosomal proteasefacilitates the breakdown of unwanted and damaged proteins in the endo-lysosomal pathway. Moreoverit plays specific rolessuch as contributing to major histocompatibility complex (MHC) class II antigen presentation by aiding in the degradation of the invariant chain. Dysregulation of cathepsin S has been associated with various pathological conditionssuch as cancerarthritisand cardiovascular disease. Cathepsin S is useful for the study of enzyme kineticsscreening inhibitorsand selectivity profiling. It is also used as a biomarker for atherosclerosisdiabetesadiposityand atherogenesis. Moreoverit acts as a promising target against brain-penetrating and for the treatment of multiple sclerosis and neuropathic pain. |
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