| Identification | Back Directory | [Name]
3'-DEOXYADENOSINE 5'-TRIPHOSPHATE SODIUM SALT | [CAS]
71997-32-5 | [Synonyms]
Cordycepin 5′-triphosphate
cordycepin 5'-triphosphate sodium
3'-deoxyadenosine 5'-triphosphate
Cordycepin-5''-triphosphoric acid
CORDYCEPIN 5'-TRIPHOSPHATE SODIUM SALT
3'-deoxyadenosine-5'-triphosphate sodium
3'-DEOXYADENOSINE 5'-TRIPHOSPHATE SODIUM SALT
Sodium (2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(((hydroxy((hydroxy(phosphonooxy)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-olate | [Molecular Formula]
C10H17N5NaO12P3 | [MDL Number]
MFCD32067416 | [MOL File]
71997-32-5.mol | [Molecular Weight]
515.18 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [InChIKey]
FRGBONDYLMUOMH-UHFFFAOYSA-N | [SMILES]
[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O |
| Hazard Information | Back Directory | [Uses]
Cordycepin 5′-triphosphate sodium salt has been used:
- as a transcriptional inhibitor in RNA decay assay
- to inhibit polyadenylation in HEK293T cells before harvesting for in- vitro interaction studies through co-immunoprecipitation (co-Ips)
- as a positive control in in vitro assays for polymerase inhibition
- as a precursor to produce cordycepin monophosphate
| [Definition]
ChEBI: Cordycepin triphosphate is a purine ribonucleoside 5'-triphosphate. It has a role as an antimetabolite, an antifungal agent, an antineoplastic agent and an antiviral agent. It is functionally related to a cordycepin. | [General Description]
Cordycepin (3′-deoxyadenosine) is a cytotoxic adenosine analog and a bioactive agent extracted from Cordyceps militaris. Cordycepin 5′-triphosphate is a toxic derivative of cordycepin. | [Biochem/physiol Actions]
Cordycepin exhibits various metabolic effects by activating AMP-activated protein kinase (AMPK) in humans. Cordycepin triphosphate inhibits picornavirus polymerase-specific RNA synthesis by blocking in vitro [3H]GMP incorporation. It also retards cell growth by inhibiting RNA synthesis. |
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