| Identification | Back Directory | [Name]
LEUKOTRIENE C4 | [CAS]
72025-60-6 | [Synonyms]
LTC4
leukotrienec
LEUKOTRIENE C4
5s,6r-ltc(sub4)
leukotrienec(sub1)
leukotrienec(sub4)
LTC4 (Leukotriene C4)
GWNVDXQDILPJIG-SWOVEEFNSA-N
Leukotriene C4 MaxSpec Standard
LEUKOTRIENE C4 ( ETHANOL SOLUTION)
Leukotriene C4 Lipid Maps MS Standard
Leukotriene C - CAS 72025-60-6 - Calbiochem
(r-(r*,s*-(e,e,z,z)))-ma-glutamyl-l-cysteinyl)
5S-HYDROXY-6R-(S-GLUTATHIONYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID
glycine,n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-n-l-gam
5(S)-HYDROXY-6(R)-S-GLUTATHIONYL-7-TRANS-9-TRANS-11-CIS-14-CIS-EICOSATETRAENOIC ACID
L-γGlu-S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-Cys-Gly-OH
Glycine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-
N-[S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-L-γ-glutamyl-L-cysteinyl]glycine
6-[2-(4-amino-4-carboxy-butanoyl)amino-2-(carboxymethylcarbamoyl)ethyl]sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid
N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-N-(L-γ-glutamyl)-L-cysteinyl]glycine | [EINECS(EC#)]
686-872-9 | [Molecular Formula]
C30H47N3O9S | [MDL Number]
MFCD00151079 | [MOL File]
72025-60-6.mol | [Molecular Weight]
625.77 |
| Chemical Properties | Back Directory | [Boiling point ]
974.3±65.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [Fp ]
11 °C | [storage temp. ]
−20°C
| [solubility ]
50mg/mL in DMSO, or in DMF | [form ]
Liquid | [pka]
2.21±0.10(Predicted) | [color ]
Colorless to light yellow | [InChIKey]
GWNVDXQDILPJIG-NXOLIXFESA-N | [SMILES]
OC(CCC[C@H](O)[C@H](SC[C@@H](C(NCC(O)=O)=O)NC(CC[C@H](N)C(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)=O |
| Hazard Information | Back Directory | [Description]
Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. | [Uses]
LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions. | [Definition]
ChEBI: A leukotriene that contains cysteine in their structure. | [IC 50]
Human Endogenous Metabolite | [References]
[1] PIPER P J. Formation and actions of leukotrienes.[J]. Physiological reviews, 1984, 64 2: 744-761. DOI: 10.1152/physrev.1984.64.2.744
[2] CHARLES THOMPSON. Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription.[J]. The Journal of Biological Chemistry, 2008: 1974-1984. DOI: 10.1074/jbc.m608197200 |
|
|