| Identification | Back Directory | [Name]
2-iodo-N-phenylacetamide | [CAS]
7212-28-4 | [Synonyms]
2-iodo-N-phenylacetamide
Acetamide, 2-iodo-N-phenyl- | [Molecular Formula]
C8H8INO | [MDL Number]
MFCD16170501 | [MOL File]
7212-28-4.mol | [Molecular Weight]
261.06 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: 2-Chloro-N-phenylacetamide (18 mmol) and potassium iodide (4.4 g, 27 mmol) were dissolved in acetone (40 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue and a solid was precipitated, collected by filtration and dried to give 2-iodo-N-phenylacetamide.
1.5.1. Synthesis of 2-iodo-N-phenylacetamide (6a): operated according to the general method described above, the target compound was obtained in 84.5% yield as a white solid with a melting point of 144-146 °C. 1H NMR (300 MHz, CDCl3) δ 3.86 (s, 2H, ICH2), 7.15 (t, J = 7.4 Hz, 1H, ArH). 7.35 (t, J = 7.8 Hz, 2H, ArH), 7.50 (d, J = 7.9 Hz, 2H, ArH), 7.69 (s, 1H, NH). calculated ESI-MS value 262.0 [M + H]+, measured value 262.0 [M + H]+. | [References]
[1] Patent: CN107880037, 2018, A. Location in patent: Paragraph 0010
[2] Patent: CN107880036, 2018, A. Location in patent: Paragraph 0011
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 4, p. 1360 - 1364
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53, # 6, p. 733 - 739
[5] Archiv der Pharmazie, 2008, vol. 341, # 11, p. 690 - 695 |
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