| Identification | Back Directory | [Name]
CALCIMYCIN A23187 HEMIMAGNESIUM SALT | [CAS]
72124-77-7 | [Synonyms]
a23187hemimagnesium salt
Calcimycin hemimagnesium
CALCIMYCIN HEMIMAGNESIUM SALT
CALCIMYCIN A23187 HEMIMAGNESIUM SALT
calcium ionophore A23187 hemimagnesium
CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT
CALCIUM IONOPHORE A23187 HEMIMAGNESIUM SALT BIOCHEMIKA
A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt | [Molecular Formula]
C58H72MgN6O12 | [MDL Number]
MFCD00151203 | [MOL File]
72124-77-7.mol | [Molecular Weight]
1069.53 |
| Hazard Information | Back Directory | [Uses]
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4]. | [in vivo]
Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5]. | Animal Model: | Mice (ICR, 25-30 g)[5] | | Dosage: | 2.5 or 7.5 nM | | Administration: | Intrapleurally | | Result: | Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
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| [References]
[1] Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. DOI:10.1128/AAC.01130-10
[2] Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. DOI:10.1038/sj.embor.embor722
[3] Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. DOI:10.4161/auto.25900
[4] Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. DOI:10.1016/j.bbagen.2017.09.010
[5] Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. DOI:10.1007/BF00180016 |
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